Modified en bloc resection is a hybrid technique involving piecemeal resection of the exophytic part of the bladder tumour, followed by en bloc resection of the tumour base. In this study, we shall investigate the efficacy of modified en bloc resection for patients with bladder tumours of ≥3cm in size.
Conditions: Bladder Cancer, Bladder Neoplasm, Bladder Tumor
Eligibility Criteria
Inclusion Criteria
- Age 18 to 80 years old with informed consent
- Bladder tumours with maximal dimension of ≥ 3cm
Exclusion Criteria
- Bladder tumour detected during intravesical Bacillus Calmette-Guerin therapy (These patients warrant more aggressive treatment, i.e. radical cystectomy)
- Estimated glomerular filtration rate of \<60mL/min.
- Presence of clinically significant cardiovascular disease (History of acute myocardial infarction, presence of uncontrolled angina within 3 months before screening, New York Heart Association Class III or IV congestive heart failure, presence of ventricular arrhythmias, or presence of second-degree or third-degree heart block)
- Presence of GOLD Stage III or IV chronic obstructive pulmonary disease
- History of bleeding disorder or use of anti-coagulant
- Presence of other active malignancy
- ECOG performance status ≥ 2 (Ambulatory and capable of all self care but unable to carry our any work activities. Confined to bed or chair less than 50% of waking hours)
- Pregnancy
- Presence of metallic foreign body or implant which is not MRI compatible
- Known history of claustrophobia
Eligibility criteria are kept as the original English records from ClinicalTrials.gov; actual eligibility is determined by the research team's formal assessment and the informed consent form. Source: ClinicalTrials.gov, updated automatically every two weeks. Last synced: 2026年10月8日.