即将开始 NCT07615556

ctDNA突变与甲基化状态用于可疑肺结节患者肺癌早期检测

肺癌不适用I 期II 期

肺癌在亚洲常见,其流行病学及治疗方式与西方国家的肺癌有所不同。肺癌可以早期发现,但大多数早期肺癌在影像上表现为具有可疑特征的肺结节。对具有可疑肺结节的受试者进行检查及监测是一项临床难题。

适应症:Lung Nodules、Lung Cancer Screening、Suspected Lung Cancer

入组条件

纳入标准

  • Age 45 - 80 years;
  • Suspicious lung nodules (\> 0.5 - 30mm in longest diameter, non-calcified) found within the past six months, or if PET scan has been done before, the specific uptake value (SUV) should be more than 1

排除标准

  • Age \< 45 or \> 80;
  • Lung nodules of \< 0.5 cm in longest diameter, or with calcification seen in imaging;
  • Known lung cancer or lung metastasis before, or history of extra-pulmonary cancer;
  • Active tuberculosis;
  • Clinical unstable conditions including untreated ischemic heart disease or arrhythmia, uncontrolled airway disease;
  • Unwillingness to undergo invasive investigation like bronchoscopy;
  • Unable to provide informed written consent.

入组条件维持 ClinicalTrials.gov 原始英文登记资料,实际入组资格以研究团队的正式评估与受试者知情同意书为准。资料来源:ClinicalTrials.gov,每两周自动更新,最后同步:2026年10月8日。