由于证据不足，目前不建议对非吸烟者进行肺癌筛查。新兴证据显示，一等亲家族史是亚洲非吸烟者罹患肺癌的强烈风险因素。在亚洲，资源匮乏是成功实施肺癌筛查的主要挑战。人工智能（AI）是克服此资源限制的具前景工具。
适应症：Lung Cancer
入组条件
纳入标准
- Patients are eligible to be included in the study only if all of the following criteria apply:
- Age 50-75 years old
- Non-smoker (defined as less than 100 cigarettes in lifetime)
- Having a first-degree family history of lung cancer
- Physically fit for curative treatment if early-staged lung cancer is found
- Able to provide written informed consent
- Consent to follow up visits and follow up CT scan if indicated
- Consent to blood taking for translational research
排除标准
- History of malignancy
- Smoking history (defined as more than 100 cigarettes in lifetime)
- Clinical symptoms suspicious for lung cancer e.g. haemoptysis, chest pain, weight loss
- Medical comorbidities that preclude curative treatment (surgery) for lung cancer, such as severe heart disease, acute or chronic respiratory failure, home oxygen therapy, bleeding disorder
- Pregnant ladies or ladies planning for conception
- History of tuberculosis or interstitial lung disease
- Pneumonia requiring antibiotic treatment within the last 12 weeks
- CT thorax or chest performed within 2 years (including LDCT, PET-CT, MRI thorax or suspicious of lung cancer)
- Unable or unwilling to provide written informed consent
入组条件维持 ClinicalTrials.gov 原始英文登记资料，实际入组资格以研究团队的正式评估与受试者知情同意书为准。资料来源：ClinicalTrials.gov，每两周自动更新，最后同步：2026年10月8日。