联合肝脏分隔及门静脉结扎分期肝切除术（ALPPS）是一种新手术程序，可为计划接受大范围肝切除而残余肝脏较小的患者诱导快速肝脏再生。这是一项两阶段手术，第一阶段包括门静脉结扎及将右肝与左肝分离。
适应症：Liver Cancer
入组条件
纳入标准
- Patients with a diagnosis of malignant liver tumor contemplating for extended right hepatectomy or right trisectionectomy
- Patient consent
- Age \>/= 18
- FLR/ESLV \</= 30%
- Indocyanine green clearance rate at 15 mins : \< 18%
- Platelet count \> 100x10\^9/L
- Child A cirrhosis (due to hepatitis B/C virus, or alcohol, or autoimmune disease)
- American Society of Anaesthesiology score \< 3
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Technical factors eligible for laparoscopic ALPPS
- single long-segment portal
排除标准
- Absence of consent
- Decompensated liver disease as indicated by the presence of ascites, varices and hepatic encephalopathy
- ECOG performance status \>/= 3
- Main portal vein thrombosis
- FLR/ESLV \> 30%
- Technical factors not eligible for laparoscopic ALPPS
- Short-segment right portal vein or early bifurcation of right anterior/posterior portal vein, or other portal vein anomalies
- Large tumor size with diameter \> 5 cm
- Intolerance to CO2 pneumoperitoneum
入组条件维持 ClinicalTrials.gov 原始英文登记资料，实际入组资格以研究团队的正式评估与受试者知情同意书为准。资料来源：ClinicalTrials.gov，每两周自动更新，最后同步：2026年10月8日。