招募中 NCT04475705

Propofol与Sevo用于儿童肿瘤手术之比较

未指定Phase IV

背景: 回顾性研究及统合分析显示,与propofol为基础的全静脉麻醉(TIVA)相比,以吸入性麻醉为基础的癌症手术后5年生存率有所降低。迄今为止,尚无前瞻性试验发表评估麻醉技术对循环肿瘤细胞(CTC)、氧化应激及癌症手术后复发率的影响。

适应症:Solid Tumor、Carcinoma、Malignancy、Cancer

入组条件

纳入标准

  • patients coming for elective primary solid tumor resection for curative intent in Hong Kong Children's Hospital
  • AND patients \> 5kg
  • AND patients within age limit

排除标准

  • Autoimmune / Chronic inflammatory diseases e.g. Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA) etc.
  • Current Steroid therapy
  • Surgery for tumour removal in the past year
  • Allergy to Propofol
  • intraoperative use of nitrous oxide
  • Patient susceptible to Malignant Hyperthermia
  • Patients / parents / legal guardians showing preference in anaesthetic techniques during recruitment process

入组条件维持 ClinicalTrials.gov 原始英文登记资料,实际入组资格以研究团队的正式评估与受试者知情同意书为准。资料来源:ClinicalTrials.gov,每两周自动更新,最后同步:2026年10月8日。