手术部位感染（SSI）并不罕见，尤其是在特定高风险组别，包括脊柱畸形及肿瘤（即转移性脊柱手术）手术。目前已采用广受认可的措施以减少手术部位感染，而近年局部使用 Vancomycin 粉末亦日益普及。
适应症：Spinal Deformity、Trauma、Spinal Tumor、Surgical Site Infection
入组条件
纳入标准
- Female or male adult with age ≥18 years
- Undergoing open posterior spinal surgery with instrumentation indicated for spinal deformity, trauma and tumor
- Able to understand the nature, scope and possible consequences of participation in the study
- Appropriate voluntary written informed consent have been provided by patients
排除标准
- Has been treated with antibiotics due to primary spinal infection (i.e. spondylodiscitis) within 1 year prior to surgery
- Ongoing treatment with antibiotics for other infections
- Undergoing minimally invasive surgery or anterior-only surgical approaches or deformity correction surgery for adolescent idiopathic scoliosis (inherent low-risk for surgical site infections18)
- Undergoing decompression-only surgery for cervical spine, spinal deformity, trauma and tumors
- Has known history of allergy to vancomycin, penicillin and other glycopeptides (teicoplanin)
- Has history of vancomycin resistance
- Pregnancy
入组条件维持 ClinicalTrials.gov 原始英文登记资料，实际入组资格以研究团队的正式评估与受试者知情同意书为准。资料来源：ClinicalTrials.gov，每两周自动更新，最后同步：2026年10月8日。