The investigators propose a randomized controlled trial to evaluate the clinical effectiveness of low-dose computed tomography (LDCT) for lung cancer screening in high-risk Chinese ever-smokers aged 50-79 years in Hong Kong and to assess the cost-effectiveness of implementing LDCT for lung cancer screening in the local setting.
Conditions: Lung Cancer, Lung Cancer Screening
Eligibility Criteria
Inclusion Criteria
- Adults aged between 50 and 79 years
- Current smokers or ex-smokers quitted for less than 10 years, with a history of cigarette smoking equivalent to at least 20 pack-years
Exclusion Criteria
- Non-Chinese population
- Individuals who are not mentally competent to provide informed consent (e.g., those with a history of dementia)
- Individuals with a known prior diagnosis of lung cancer or detection of lung nodules
- Individuals with a history of other cancers within the last five years or currently under treatment
- Individuals who have undergone a CT scan of the thorax in the previous 12 months
- Individuals who are either unwilling to undergo a chest LDCT scan, or having a condition that prevents them from having a LDCT scan (for example, pregnancy or inability to lie flat on the CT table)
Eligibility criteria are kept as the original English records from ClinicalTrials.gov; actual eligibility is determined by the research team's formal assessment and the informed consent form. Source: ClinicalTrials.gov, updated automatically every two weeks. Last synced: 2026年10月8日.