Completed NCT05797649

Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)

未指定N/A

To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).

Conditions: Pleural Effusion, Heart Failure, Malignant Neoplasm, Fluid Overload, Hypoalbuminemia, Renal Failure, Cirrhosis, Infections

Eligibility Criteria

Inclusion Criteria

  • Patients hospitalized for heart failure and pleural effusion
  • Pleural tapping indicated for pleural fluid analysis.
  • Aged 18 years old or above

Exclusion Criteria

  • History of intrapleural therapy (including talc and fibrinolytic) in the ipsilateral pleural space.
  • History of surgical decortication or pleurodesis in the ipsilateral pleural space.
  • Ipsilateral thoracic or cardiac surgery in the past 3 months.
  • Failure to obtain informed consent due to the patient's refusal or cognitive impairment.

Eligibility criteria are kept as the original English records from ClinicalTrials.gov; actual eligibility is determined by the research team's formal assessment and the informed consent form. Source: ClinicalTrials.gov, updated automatically every two weeks. Last synced: 2026年10月8日.