背景：研究強調居家運動對患有化療引起的神經病變（CIN）的癌症康復者具有潛在益處；然而，其在緩解CIN相關感覺運動功能障礙及症狀方面的效果並不一致，且一般較為溫和。非侵入性迷走神經刺激（nVNS）已成為CIN復康中一種有前景的輔助療法。
適應症：Chemotherapy-induced Neuropathy
收案條件
納入條件
- Hong Kong residents who can communicate in Cantonese, Mandarin, or English;
- Aged 18 years or older;
- Cancer survivors with complete disease remission after radical treatment;
- Completed a chemotherapy regimen with radical intent that included at least one of the following agents for a minimum of 3 months:
- Platinum compounds (e.g., cisplatin, carboplatin, oxaliplatin);
- Taxanes (e.g., paclitaxel, docetaxel);
- Have CIN of at least grade 2 assessed by a clinician based on the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0 (NCI-CTCAE 5.0), or self-rate ≥ 2 points on at least one item in the 4-item Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaire;
- Physically capable of engaging in exercise and assessments, as determined by the ability to complete the 6MWT;
- Able to provide written informed consent.
排除條件
- Known history of peripheral neuropathy or related symptoms prior to chemotherapy;
- History of heart disease;
- Bradycardia (heart rate \< 60 beats per minute);
- Pregnancy;
- Presence of active implants, such as cardiac pacemakers, cochlear implants, and implanted neurostimulators;
- Known metastasis to the central or peripheral nervous system;
- Any physical or mental handicap;
- History of alcohol or illegal drug abuse;
- Using a hearing aid device on the left ear;
- Receiving other non-pharmacological treatments for CIN within the past 2 months;
- Engaging in over 30 minutes of exercise for 2 or more days per week prior to enrollment;
- Any wound, infection, skin allergy, or deformity in the left ear;
- Any other medical contraindication to exercise and/or nVNS as determined by the treating oncologist.
收案條件維持 ClinicalTrials.gov 原始英文登錄資料，實際收案資格以研究團隊的正式評估與受試者同意書為準。資料來源：ClinicalTrials.gov，每兩週自動更新，最後同步：2026年11月5日。