本研究的目的在於確定個人藥物基因（PG）分析能否為接受首個週期AC（Adriamycin + Cyclophosphamide）或FEC（Fluorouracil + Epirubicin + Cyclophosphamide）化療的患者，實現止吐方案的最佳選擇。
適應症：Breast Cancer
收案條件
納入條件
- Chinese patient, female \>/=18 and \< 75 years of age.
- Patient is diagnosed with early breast cancer.
- Patient is naïve to emetogenic chemotherapy moderately or highly emetogenicity.
- Patient is scheduled to receive her first course of neoadjuvant/adjuvant chemotherapy for breast cancer follows: AC: Intravenous (IV) Adriamycin 60 mg/m\^2 + Cyclophosphamide 600 mg/m\^2, given as 14-day cycle or 21-day cycle, or FEC: IV Fluorouracil 500 mg/m\^2 + Epirubicin 50 mg/m\^2 + Cyclophosphamide 500 mg/m\^2, given as 21-day cycle
- Patient has a predicted life expectancy of 4 months.
- Patient has ECOG (Eastern Cooperative Oncology Group) Performance Status of 0-1.
- Premenopausal female patients must not be pregnant (documented negative urine pregnancy test).
- Patient is able to read, understand and complete study questionnaires and diary, including questions requiring a visual analog scale (VAS) response.
- Patient understands the procedures and agrees to participate in the study by giving written informed consent.
排除條件
- Patient with advanced breast cancer.
- Patient receiving cisplatin or any other chemotherapy of higher emetogenic potential, except for cyclophosphamide and doxorubicin in the regimens described above.
- Patients who are scheduled to receive concurrent radiation as part of their chemotherapy regimen for their malignancy
- Patients who experience any vomiting or grade 2-3 nausea per Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v 4.03) in the 24 hours before Day 1 of chemotherapy
- Patient has a history of treatment with moderately to highly emetogenic chemotherapy.
- Patient has an active infection (e.g., pneumonia, systemic fungal infection) or any uncontrolled disease (e.g., diabetes mellitus, hypertension) which, in the opinion of the investigator, might confound the results of the study or pose unwarranted risk.
- Patient with history of glaucoma, dementia, seizures, Parkinson's disease, Neuroleptic Malignant Syndrome (NMS), thromboembolic events.
- Patient currently uses any illicit drugs, including marijuana, or has current evidence of alcohol abuse as determined by the investigator.
- Patient is mentally incapacitated or has a significant emotional or psychiatric disorder that, in the opinion of the investigator, precludes study entry.
- Patients who are regular alcohol drinker or smoker
- Patient has a history of any illness that, in the opinion of the investigator, might confound the results of the study or pose unwarranted risk.
- Patient has a history of hypersensitivity to aprepitant, ondansetron or dexamethasone.
- Patients who have phenylketonuria and abnormal uric acid.
- Any investigational drugs taken within 4 weeks prior to Day 1 of cycle 1, and/or is scheduled to receive any investigational drug during the study.
收案條件維持 ClinicalTrials.gov 原始英文登錄資料，實際收案資格以研究團隊的正式評估與受試者同意書為準。資料來源：ClinicalTrials.gov，每兩週自動更新，最後同步：2026年10月8日。