招募中 NCT07130682

MRI引導下兩次分次質子治療前列腺癌:一項第二期試驗

前列腺癌不適用PSMA

本研究正在測試一種使用質子治療(PT)的較短程前列腺癌治療方法,質子治療非常精準,與傳統放射治療相比可能引起較少副作用。然而,其費用昂貴且許多患者難以獲得。為使其更可負擔及更易獲得,本研究正在測試2次分次的立體定向身體質子治療(SBPT)能否與標準5次治療同樣安全有效。

適應症:Prostate Cancer Patients Treated by Radiotherapy

收案條件

納入條件

  • Men aged \< 18 years with histologically confirmed low- or intermediate-risk prostate cancer per NCCN guidelines
  • Eastern Cooperative Oncology Group (ECOG) performance status \<2
  • Ability to undergo magnetic resonance imaging (MRI) simulation scans without absolute contraindications, such as cardiac implantable electronic devices
  • Ability to complete the Expanded Prostate Cancer Index Composite (EPIC) questionnaire

排除條件

  • History of inflammatory bowel disease or other cancers (except prostate cancer)
  • Prior pelvic radiotherapy, chemotherapy, radical prostatectomy, cryosurgery, or focal therapy (e.g. high-intensity focused ultrasound \[HIFU\]) for prostate cancer
  • History of bladder neck or urethral stricture
  • Transurethral resection of the prostate (TURP) \< 8 weeks prior to SBPT
  • Prostate volume \> 100cc on MRI
  • Unilateral or bilateral hip replacements
  • Nodal or distant metastases, as indicated by computed tomography (CT), MRI, or prostate-specific membrane antigen (PSMA) positron emission tomography (PET) scans
  • Previous androgen deprivation therapy (ADT) lasting more than 6 months

收案條件維持 ClinicalTrials.gov 原始英文登錄資料,實際收案資格以研究團隊的正式評估與受試者同意書為準。資料來源:ClinicalTrials.gov,每兩週自動更新,最後同步:2026年10月8日。