招募中 NCT05629845

EUS引導治療與傳統內窺鏡治療預防肝細胞癌患者靜脈曲張再出血的比較

肝癌食道癌不適用

儘管已採用傳統內窺鏡療法治療食道及胃靜脈曲張(EV、GV),肝細胞癌(HCC)合併靜脈曲張出血患者的再出血率仍然偏高。據報道,靜脈曲張再出血的次級預防可改善HCC患者的預後,但最佳內窺鏡治療方式尚未明確。在此難以處理的人群中,傳統內窺鏡治療後靜脈曲張再出血率仍然相當高。

適應症:Hepatocellular Carcinoma、Variceal Bleeding

收案條件

納入條件

  • Consecutive HCC patients age 18 or older with recent (within 4 weeks of the episode) EV or GV bleeding successfully controlled by conventional endoscopic therapies (VBL for EV or glue injection for GV)
  • Able to provide written informed consent to participate in the study and comply with the study procedures

排除條件

  • Unable to provide written informed consent
  • Contraindications for endoscopy due to underlying comorbidities
  • HCC patients with non-variceal source of gastrointestinal bleeding
  • Refractory coagulopathy (INR\>1.5) or refractory thrombocytopenia (platelets \<50,000) despite blood product transfusion
  • Moribund patients from terminal illness

收案條件維持 ClinicalTrials.gov 原始英文登錄資料,實際收案資格以研究團隊的正式評估與受試者同意書為準。資料來源:ClinicalTrials.gov,每兩週自動更新,最後同步:2026年10月8日。