這項多中心、雙盲隨機對照試驗旨在評估一種新型口服合生元配方（SMT04）在結直腸晚期腫瘤內窺鏡切除後減少晚期腺瘤復發及結直腸腫瘤相關細菌基因標記的療效。
適應症：Colorectal Neoplasms、Colorectal Adenoma、Colorectal Cancer、Advanced Adenoma
收案條件
納入條件
- Subjects who have advanced colorectal neoplasia\* removed and confirmed by histopathology;
- They have received high quality colonoscopies before or during endoscopic resection (defined as a full colonoscopy with successful caecal intubation, and a Boston Bowel Preparation Scale ≧2 in each colonic segment) with no residual colorectal neoplasia;
- Aged 18-90 years old;
- Written informed consent obtained
- An advanced colorectal neoplasia is defined as an advanced adenoma, sessile serrated lesion or non-invasive colorectal cancer (stage Tis or T1a). Advanced adenoma is defined as an adenoma larger than 10mm, and/or with villous component ≥20%, and/or harboring high grade dysplasia.
排除條件
- Known residual colorectal neoplasia not removed (except hyperplastic polyps);
- Contraindications to endoscopic resection due to deep submucosal invasion (stage T1b or above);
- Prior surgical resection of colon;
- Personal history of hereditary polyposis syndrome or inflammatory bowel disease;
- Known pregnancy or lactation;
- Immunocompromised status (e.g. on immunosuppressants (except 5-aminosalicylic acid or short term use of corticosteroids \<4 weeks), on chemotherapy, bone marrow or solid organ transplant, human immunodeficiency virus, congenital immune deficiency);
- Advanced comorbid conditions (defined as American Society of Anesthesiologists grade 4 or above);
- Refusal to undergo surveillance colonoscopy.
收案條件維持 ClinicalTrials.gov 原始英文登錄資料，實際收案資格以研究團隊的正式評估與受試者同意書為準。資料來源：ClinicalTrials.gov，每兩週自動更新，最後同步：2026年10月8日。