已完成 NCT05337137

Nivolumab及Relatlimab聯合Bevacizumab治療晚期肝癌的研究

肝癌膽道癌肉瘤Phase IIII 期IV 期

本研究旨在評估nivolumab、relatlimab及bevacizumab三聯治療與nivolumab及bevacizumab相比,在未經治療的晚期/轉移性肝細胞癌(HCC)參與者中的安全性及療效。

適應症:Carcinoma, Hepatocellular

收案條件

納入條件

  • Histologically confirmed advanced/metastatic hepatocellular carcinoma (HCC)
  • Naïve to systemic therapy for advanced/metastatic HCC (prior neo-adjuvant or adjuvant immunotherapy is permitted if recurrence occurs ≥ 6 months after treatment completion and the case is discussed with BMS medical team)
  • Child-Pugh score of 5 or 6 (ie, Child-Pugh A)
  • Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

排除條件

  • Known fibrolamellar HCC, sarcomatoid HCC or mixed cholangiocarcinoma and HCC
  • Prior allogenic stem cell or solid organ transplantation
  • Untreated symptomatic central nervous system (CNS) metastases
  • Clinically significant ascites as defined by:
  • i) Prior ascites that required treatment and requires on-going prophylaxis, or ii) Current ascites requiring treatment

收案條件維持 ClinicalTrials.gov 原始英文登錄資料,實際收案資格以研究團隊的正式評估與受試者同意書為準。資料來源:ClinicalTrials.gov,每兩週自動更新,最後同步:2026年10月8日。