本研究旨在評估 ribociclib（LEE011）聯合其他藥物的長期安全性，並為目前正在一項已達到主要目標的 Novartis 資助全球研究中接受 ribociclib 聯合其他藥物治療且持續獲得臨床獲益的參與者，提供試驗後用藥（PTA）。
適應症：Metastatic Breast Cancer
收案條件
納入條件
- Signed informed consent must be obtained prior to participation in the study.
- Participant is currently participating in a Novartis sponsored global study (parent study), receiving treatment with ribociclib in combination with other drugs and the parent study has fulfilled its primary objective(s).
- Willingness and ability to comply with scheduled visits, treatment plans and any other study procedures.
- Participant must have been receiving treatment with ribociclib for at least 6 cycles in the parent study.
- Participant must have evidence of clinical benefit as determined by the Investigator.
排除條件
- Permanent discontinuation of ribociclib in the parent study due to toxicity or disease progression, non-compliance to study procedures, withdrawal of consent or any other reason as stipulated in parent protocol.
- Participant currently has unresolved toxicities for which ribociclib dosing has been interrupted in the parent study (participants meeting all other eligibility criteria may be enrolled once toxicities have resolved to allow ribociclib dosing to resume).
- Local access to commercially available ribociclib and reimbursed (except for US enrolled participants from parent protocol CLEE011A2404 meeting all other eligibility criteria).
- Women of child-bearing potential defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during the study treatment and for 21 days after stopping the treatment. Highly effective contraception methods include:
- Total abstinence
- Female sterilization
- Male partner sterilization
- Placement of an intrauterine device (IUD)
- Male contraception during ribociclib use by male participants is not required unless it is necessary due to the safety profile of other medications a participant is taking or by local regulations.
收案條件維持 ClinicalTrials.gov 原始英文登錄資料，實際收案資格以研究團隊的正式評估與受試者同意書為準。資料來源：ClinicalTrials.gov，每兩週自動更新，最後同步：2026年10月8日。