内镜切除术已日益广泛应用于小型胃肠道基质瘤（GIST）的治疗，惟最佳切除方法尚未确定。本研究旨在比较内镜全层切除术（EFTR）与黏膜下隧道内镜切除术（STER）治疗临床小型胃GIST的疗效。
适应症：Small Size Gastrointestinal Stromal Tumors、GIST
入组条件
纳入标准
- Consecutive adult patients age \>=18 and \<=75 with a clinical diagnosis of gastric GIST who opted for endoscopic resection would be screened for eligibility.
- Presence of gastric subepithelial tumor on diagnostic upper endoscopy, and
- Diagnostic EUS and CT scan with intravenous contrast suspicious of GIST arising from muscularis propria layer, size with maximum diameter \>=1.0cm and \<= 3.5cm, and
- Absence of high risk features, including irregular margins, invasion to surrounding organs, lesion hypervascularity, and
- Endoscopic morphology and location deemed feasible with both EFTR and STER by an expert endoscopist, or
- Histological confirmation of GIST through EUS guided fine needle biopsy (Optional, based on recommendation from guidelines)
排除标准
- Patients with tumors deemed not suitable for endoscopic resection (Either EFTR or STER), due to unfavourable location, high risk morphology, or any other reasons.
- Patients with multiple tumors.
- Patients unable or unwilling to provide consent.
- Previous esophageal or gastric surgery.
- Patients with significant cardiorespiratory comorbidities which may limit their ability to undertake general anesthesia for the procedure, including ASA grade III or above.
- Pregnant women or those planning pregnancy or breastfeeding women.
- Uncorrectable coagulopathy defined by international normalized ratio (INR) \> 1.5 or platelet count \< 50000/µl.
- Patients on double anti-platelet agents or anti-coagulation (Warfarin, heparin or other direct oral anticoagulants)
入组条件维持 ClinicalTrials.gov 原始英文登记资料，实际入组资格以研究团队的正式评估与受试者知情同意书为准。资料来源：ClinicalTrials.gov，每两周自动更新，最后同步：2026年10月8日。