研究人员计划通过血浆进行全面的分子图谱分析，主要目的是利用此分析形式指导后续治疗选择。本研究将有助于更深入了解亚洲肺癌治疗中ALK耐药的情况，并通过将继发突变与能提供最大覆盖范围的ALK抑制剂进行「配对」，最终带来持久的疗效，从而改善临床结局。
适应症：Non-small Cell Lung Cancer、ALK-Positive Lung Cancer
入组条件
纳入标准
- Patients with advanced ALK fusion oncogene positive lung adenocarcinoma that have progressed after 1-2 ALK inhibitors, with at least one prior line of 2nd generation ALKi (i.e. Ceritinib, Alectinib, Brigatinib or Ensartinib)
- The availability of sufficient plasma
- Age ≥ 21 years
- WHO performance status ≤ 2
- Life expectancy of ≥ 21 weeks
- Patients should have adequate organ function for potential consideration into clinical trials (routine blood tests are valid within 14 days before enrollment):
- Adequate bone marrow function as shown by: ANC ≥ 1.0x10\^9/L, Platelets ≥ 75x10\^9/L, Hb ≥ 7.5 g/dL
- Alanine aminotransferase (ALT) and aspirate aminotransferase (AST) normal range (or ≤ 3.0xULN if liver metastases are present)
- Willing to provide signed informed consent
- Patients whom do not fulfill the above criteria may be discussed on a case-by-case basis within the study team, for potential enrolment
排除标准
- Received more than 2 prior ALK inhibitors (ALKi)
- Symptomatic or uncontrolled brain metastases requiring concurrent treatment inclusive but not limited to surgery and radiation. Stable/ tailing doses of corticosteroids is permitted
入组条件维持 ClinicalTrials.gov 原始英文登记资料，实际入组资格以研究团队的正式评估与受试者知情同意书为准。资料来源：ClinicalTrials.gov，每两周自动更新，最后同步：2026年10月8日。